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M9480528.TXT
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1994-08-20
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Document 0528
DOCN M9480528
TI Association between anti-human immunodeficiency virus type 1 (HIV-1)
antibody-dependent cellular cytotoxicity antibody titers at birth and
vertical transmission of HIV-1.
DT 9410
AU Jenkins M; Landers D; Williams-Herman D; Wara D; Viscarello RR; Hammill
HA; Kline MW; Shearer WT; Charlebois ED; Kohl S; Department of
Pediatrics, University of California, San; Francisco.
SO J Infect Dis. 1994 Aug;170(2):308-12. Unique Identifier : AIDSLINE
MED/94308594
AB Because vertical transmission of human immunodeficiency virus type 1
(HIV-1) from mother to infant occurs in only 15%-35% of possible
opportunities, natural immune defenses of the mother, fetus, or neonate
may be protective against infection. The relation between
antibody-dependent cellular cytotoxicity (ADCC) antibodies and HIV-1
infection was explored in 78 neonates born to HIV-infected women. More
than 90% of sera had measurable ADCC titers against HIV-1IIIB. Infant
titers were closely correlated with maternal titers but were independent
of total IgG and total antibody reactive to the same strain in whole
virus ELISA. At birth, mean ADCC antibody levels of infants or their
mothers were the same for infants who were infected and those who
ultimately seroreverted and remained healthy. ADCC antibody titers
against HIV-1SF2 were weakly correlated with anti-HIV-1IIIB titers and
did not predict protection from HIV-1 infection. High levels of
anti-HIV-1 ADCC antibody at birth are not protective against vertical
transmission of HIV-1.
DE *Antibody-Dependent Cell Cytotoxicity Antiviral Agents/THERAPEUTIC USE
Cohort Studies Enzyme-Linked Immunosorbent Assay Female Fetal
Blood/IMMUNOLOGY Human HIV Antibodies/*BLOOD HIV Infections/DRUG
THERAPY/IMMUNOLOGY/*TRANSMISSION HIV-1/*IMMUNOLOGY Immunity,
Maternally-Acquired Infant, Newborn Pregnancy *Pregnancy
Complications, Infectious/DRUG THERAPY/IMMUNOLOGY Prospective Studies
Retrospective Studies Support, Non-U.S. Gov't Support, U.S. Gov't,
P.H.S. JOURNAL ARTICLE MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).